The 10 Most Painful Diseases

The 10 Most Painful Diseases

There are numerous people who suffer from some of the most painful diseases known to man. Chronic pain is a side effect of many common diseases; some pain can be completely eradicated, and others must be dealt with in the best way possible. The following list outlines information about some of the most painful diseases:

1. Epidermolysis bullosa

1 The 10 Most Painful Diseases
Epidermolysis bullosa, or EB, is a very rare disease that causes the skin to become extremely fragile. This disease makes the skin so sensitive, that the slightest touch or amount of friction can cause blisters to appear on the body. Eating is also a challenge for patients with EB as the disease also causes food to have the same blistering effect on the throat. Unfortunately, EB severely decreases the life expectancy of its patients as most people with the disease do not live to see 30 years.

2. Peritonitis

Peritonitis is the inflammation of the membrane that lines the abdominal wall and most abdominal organs. This disease is an infection caused by a leakage in the abdominal, a hole in the intestines, or the effects of a ruptured appendix.


The infection can be life-threatening if not treated in time. Symptoms include pain the abdominal area, bloating, nausea, fever, or the dysfunction of organs. Surgery is almost always required for the treatment of this infection.

3. Endometriosis

Many of us know at least one female that deals with the difficulties caused by endometriosis. Endometriosis is a disease that occurs when the tissue that normally lines the uterine walls grows outside of the uterus. The most common symptoms of this disease are abdominal pain and irregularities in one’s menstrual cycle.


Endometriosis can also contribute to issues regarding infertility. Although treatable, endometriosis is a chronic condition and can occur on a life-long basis.

4. Sickle Cell Anemia

Sickle Cell Anemia
Sickle Cell Anemia is a painful, rare, chronic condition that has gained a lot of attention in the recent years. Those with sickle cell anemia possess red blood cells that are shaped like a sickle or crescent. These types of red blood cells die quickly, leaving patients with a mass absence of red blood cells in their bodies. Those with sickle cell anemia may experience pain in the joints or chest, a lack of oxygen in the body, dizziness, and fatigue. This disease is treatable, however, it has unfortunately claimed several lives.

5. Arthritis

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